Lack of association between type 2 diabetes and major depression: epidemiologic and genetic evidence in a multiethnic population.

ABSTRACT: The positive association between depression and type 2 diabetes (T2D) has been controversial, and little is known about the molecular determinants linking these disorders. Here we investigated the association between T2D and depression at the clinical and genetic level in a multiethnic cohort. We studied 17,404 individuals from EpiDREAM (3209 depression cases and 14,195 controls) who were at risk for T2D and had both phenotypic and genotypic information available at baseline. The glycemic status was determined using the 2003 American Diabetes Association criteria and an oral glucose tolerance test. Major depressive episode during the previous 12 months was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnostic criteria. Twenty single-nucleotide

SUBMITTER: Samaan Z 

PROVIDER: S-EPMC4564566 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature