Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans.

ABSTRACT: We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under different experimental conditions. The TEN method involved delivering high-frequency pulsed electrical currents to ophthalmic and maxillary divisions of the right trigeminal nerve and cervical spinal nerve afferents. Under resting conditions, TEN significantly suppressed basal sympathetic tone compared to sham as indicated by functional infrared thermography of facial temperatures. In a different experiment, subjects treated with TEN reported significantly lower levels of tension and

SUBMITTER: Tyler WJ 

PROVIDER: S-EPMC4564766 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature