Low-frequency stimulation of the external globus palladium produces anti-epileptogenic and anti-ictogenic actions in rats.

ABSTRACT:

Aim

To investigate the anti-epileptic effects of deep brain stimulation targeting the external globus palladium (GPe) in rats.

Methods

For inducing amygdala kindling and deep brain stimulation, bipolar stainless-steel electrodes were implanted in SD rats into right basolateral amygdala and right GPe, respectively. The effects of deep brain stimulation were evaluated in the amygdala kindling model, maximal electroshock model (MES) and pentylenetetrazole (PTZ) model. Moreover, the background EEGs in the amygdala and GPe were recorded.

Results

Low-frequency stimulation (0.1 ms, 1 Hz, 15 min) at the GPe slowed the progression of seizure stages and shortened the after-discharge duration (ADD) during kindling acquisition. Furthermore, low-frequency stimulation significantly

SUBMITTER: Cheng H 

PROVIDER: S-EPMC4564883 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature