Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism.

ABSTRACT:

Background

Although the prevalence of obesity is higher among women than men, they are somewhat protected from the associated cardiometabolic consequences. The increase in cardiovascular disease risk seen after the menopause suggests a role for estrogens. There is also growing evidence for the importance of estrogen on body fat and metabolism in males. We hypothesized that that estrogen administration would ameliorate the adverse effects of obesity on metabolic parameters in males.

Methods

Male and female C57Bl/6 mice were fed control or obesogenic (DIO) diets from 5 weeks of age until adulthood. Glucose tolerance testing was performed at 13 weeks of age. Mice were killed at 15 weeks of age and liver and adipose tissue were collected for analysis of gene expression. A second

SUBMITTER: Dakin RS 

PROVIDER: S-EPMC4564952 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature