Prevention of vitamin D deficiency in children following cardiac surgery: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Vitamin D is a pleiotropic hormone important for the recovery of organ systems after critical illness. Recent observational studies have suggested that three out of every four children are vitamin D deficient following cardiac surgery, with inadequate preoperative intake and surgical losses playing important contributory roles. Observed associations between postoperative levels, cardiovascular dysfunction and clinical course suggest that perioperative optimization of vitamin D status could improve outcome. With this two-arm, parallel, double blind, randomized controlled trial (RCT), we aim to compare immediate postoperative vitamin D status in children requiring cardiopulmonary bypass for congenital heart disease who receive preoperative daily high dose vitamin D supplem

SUBMITTER: McNally JD 

PROVIDER: S-EPMC4564959 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature