DNA repair gene ERCC1 polymorphisms and glioma susceptibility among Chinese population: a meta-analysis.

ABSTRACT:

Background

Excision repair cross complementation group 1 (ERCC1) has been shown to be involved in the progression of glioma susceptibility. However, the results remain conflict. The aim of this study was to systematically review and evaluate the role of ERCC1 C118T and C8092A polymorphisms in glioma risk among Chinese population.

Methods

Related case-control studies were searched in online electronic databases. Odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the extracted data.

Results

Total seven articles were retrieved, including 4426 subjects (1926 were glioma patients and 2500 were matched controls). No significant heterogeneity was found between studies (I(2)=0%, P>0.01). Our results demonstrated that A allele and AA genotype of E

SUBMITTER: Jiang C 

PROVIDER: S-EPMC4565199 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature