Associations of polymorphisms of rs1015213 with primary angle closure glaucoma-recent evidence and a meta-analysis.

ABSTRACT:

Background

Primary angle closure glaucoma (PACG) has been thought to have a significantly genetic basis for a long time, and genome-wide association studies (GWAS) have identified various candidate genes including PCMTD1-ST18 rs1015213 as susceptibility loci. However, different results produced inconsistent results and make the conclusions controversial in some extent. Thus, we carried out a systematic review, attempting to summarize the recent evidence and determine the association of rs1015213 with PACG risk.

Methods

A systematic literature search was conducted to identify all published studies on associations of rs1015213 (PCMTD1-ST18) polymorphism and PACG risk up to April 30, 2015. Selection of eligible studies was undertaken by two investigators according to inclusion

SUBMITTER: Liao L 

PROVIDER: S-EPMC4565257 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature