Association analysis of selenoprotein S polymorphisms in Chinese Han with susceptibility to gastric cancer.

ABSTRACT:

Objective

selenoprotein S (SelS) gene polymorphism is closely related to a variety of malignant tumours. Here, we evaluate the association between SelS polymorphism and genetic susceptibility to gastric cancer.

Methods

A case-control study was conducted to investigate the role of two SelS single nucleotide polymorphisms (SNPs) on the susceptibility to gastric cancer. The genotypes and genotype frequencies of the SelS were determined in 260 gastric cancer patients and 278 age-matched healthy controls. Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype rs28665122 (G-105A) and rs34713741 (G-254A) within the SelS gene. The differences in the genotypic distribution between gastric cancer patients and healthy controls were analyz

SUBMITTER: Mao H 

PROVIDER: S-EPMC4565278 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature