Association of ADRB1 gene polymorphisms with pain sensitivity in a Chinese population.

ABSTRACT:

Objective

The present study aims to observe the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain sensitivity.

Methods

We analyzed the associations between pain sensitivity and ADRB1 gene SNPs (A145 G and G1165 C) in 324 Chinese patients who underwent surgery. The genotyping was performed using PCR-RFLP technique.

Results

The patients who carried the A-allele of the A145 G SNP were more sensitive to cold pressor-induced pain than those who did not carry this allele (P < 0.05). We did not found G1165 C polymorphism associated with pain sensitive in the present study. The haplotype analysis revealed A-C haplotype carriers have reduced fentanyl use in 24-h postoperative (P < 0.05).

Conclusion

ADRB1 gene polymor

SUBMITTER: Feng S 

PROVIDER: S-EPMC4565355 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature