Identification of metastasis-suppressive microRNAs in primary melanoma.

ABSTRACT:

Background

Surgical management of primary melanoma is curative for most patients with clinically localized disease at diagnosis; however, a substantial number of patients recur and progress to advanced disease. Understanding molecular alterations that influence differential tumor progression of histopathologically similar lesions may lead to improved prognosis and therapies to slow or prevent metastasis.

Methods

We examined microRNA dysregulation by expression profiling of primary melanoma tumors from 92 patients. We screened candidate microRNAs selected by differential expression between recurrent and nonrecurrent tumors or associated with primary tumor thickness (Student's t test, Benjamini-Hochberg False Discovery Rate [FDR] < 0.05), in in vitro invasion assays. We perfor

SUBMITTER: Hanniford D 

PROVIDER: S-EPMC4565532 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature