Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise.

ABSTRACT: The myocardial response to exercise is an adaptive mechanism that permits the heart to maintain cardiac output via improved cardiac function and development of hypertrophy. There are many overlapping mechanisms via which this occurs with calcium handling being a crucial component of this process. Our laboratory has previously found that the stretch sensitive TRPV2 channels are active regulators of calcium handling and cardiac function under baseline conditions based on our observations that TRPV2-KO mice have impaired cardiac function at baseline. The focus of this study was to determine the cardiac function of TRPV2-KO mice under exercise conditions. We measured skeletal muscle at baseline in WT and TRPV2-KO mice and subjected them to various exercise protocols and measured the cardiac re

SUBMITTER: Naticchioni M 

PROVIDER: S-EPMC4565583 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature