Program Code Generator for Cardiac Electrophysiology Simulation with Automatic PDE Boundary Condition Handling.

ABSTRACT: Clinical and experimental studies involving human hearts can have certain limitations. Methods such as computer simulations can be an important alternative or supplemental tool. Physiological simulation at the tissue or organ level typically involves the handling of partial differential equations (PDEs). Boundary conditions and distributed parameters, such as those used in pharmacokinetics simulation, add to the complexity of the PDE solution. These factors can tailor PDE solutions and their corresponding program code to specific problems. Boundary condition and parameter changes in the customized code are usually prone to errors and time-consuming. We propose a general approach for handling PDEs and boundary conditions in computational models using a replacement scheme for discretization.

SUBMITTER: Punzalan FR 

PROVIDER: S-EPMC4565589 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature