Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin in LNCaP xenografts.

ABSTRACT:

Purpose

Curcumin is a nontoxic, chemopreventive agent possessing multifaceted functions. Our previous study showed that curcumin inhibits androgen receptor (AR) through modulation of Wnt/β-catenin signaling in LNCaP cells. Therefore, we investigated the in vivo effects of curcumin by using LNCaP xenografts.

Materials and methods

LNCaP cells were subcutaneously inoculated in Balb/c nude mice. When the tumor volume reached greater than 100 mm(3), either curcumin (500 mg/kg body weight) or vehicle was administered through oral gavage three times weekly for 4 weeks. The expression of AR and intermediate products of Wnt/β-catenin were assessed.

Results

Curcumin had an inhibitory effect on tumor growth during the early period, which was followed by a slow increase in growth

SUBMITTER: Hong JH 

PROVIDER: S-EPMC4565901 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature