Clinical outcomes associated with respiratory virus detection before allogeneic hematopoietic stem cell transplant.

ABSTRACT:

Background

The management of respiratory virus infections prior to hematopoietic cell transplant (HCT) is difficult. We examined whether respiratory virus detection before HCT influenced the requirement for bronchoscopy, hospitalization, and overall survival following HCT.

Methods

Pre-HCT and weekly post-HCT nasal washes were collected through day 100 from patients with and without symptoms. Samples were tested by multiplex polymerase chain reaction for respiratory syncytial virus, parainfluenza viruses 1-4, influenza A and B, human metapneumovirus, adenovirus, and human rhinoviruses, coronaviruses, and bocavirus.

Results

Of 458 patients, 116 (25%) had respiratory viruses detected pre-HCT. Overall, patients with viruses detected pre-HCT had fewer days alive and out of

SUBMITTER: Campbell AP 

PROVIDER: S-EPMC4565994 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature