Nutritional Modulation of Gene Expression: Might This be of Benefit to Individuals with Crohn's Disease?

ABSTRACT: The incidence of inflammatory bowel diseases (IBD), including Crohn's disease (CD), is increasing worldwide, especially in young children and adolescents. Although hospitalized patients are usually provided with enteral or parenteral support, continuing care typically requires a trial-and-error approach to suppressing symptoms and maintaining disease remission. Current nutritional advice does not differ from general population guidelines. International collaborative studies have revealed 163 distinct genetic loci affecting susceptibility to IBD, in some of which host-microbe interactions can be seen to play an important role. The nature of these loci enables a rationale for predicting nutritional requirements that may not be evident through standard therapeutic approaches. Certain recogniz

SUBMITTER: Ferguson LR 

PROVIDER: S-EPMC4566049 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature