Glycogen Fuels Survival During Hyposmotic-Anoxic Stress in Caenorhabditis elegans.

ABSTRACT: Oxygen is an absolute requirement for multicellular life. Animals that are deprived of oxygen for sufficient periods of time eventually become injured and die. This is largely due to the fact that, without oxygen, animals are unable to generate sufficient quantities of energy. In human diseases triggered by oxygen deprivation, such as heart attack and stroke, hyposmotic stress and cell swelling (edema) arise in affected tissues as a direct result of energetic failure. Edema independently enhances tissue injury in these diseases by incompletely understood mechanisms, resulting in poor clinical outcomes. Here, we present investigations into the effects of osmotic stress during complete oxygen deprivation (anoxia) in the genetically tractable nematode Caenorhabditis elegans. Our findings demo

SUBMITTER: LaMacchia JC 

PROVIDER: S-EPMC4566277 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature