Development of a robust DNA damage model including persistent telomere-associated damage with application to secondary cancer risk assessment.

ABSTRACT: Mathematical modelling has been instrumental to understand kinetics of radiation-induced DNA damage repair and associated secondary cancer risk. The widely accepted two-lesion kinetic (TLK) model assumes two kinds of double strand breaks, simple and complex ones, with different repair rates. Recently, persistent DNA damage associated with telomeres was reported as a new kind of DNA damage. We therefore extended existing versions of the TLK model by new categories of DNA damage and re-evaluated those models using extensive data. We subjected different versions of the TLK model to a rigorous model discrimination approach. This enabled us to robustly select a best approximating parsimonious model that can both recapitulate and predict transient and persistent DNA damage after ionizing radiati

SUBMITTER: Rastgou Talemi S 

PROVIDER: S-EPMC4566481 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature