Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages.

ABSTRACT: Alveolar macrophages (AMs) reside on the luminal surfaces of the airways and alveoli where they maintain host defense and promote alveolar homeostasis by ingesting inhaled particulates and regulating inflammatory responses. Recent studies have demonstrated that AMs populate the lungs during embryogenesis and self-renew throughout life with minimal replacement by circulating monocytes, except under extreme conditions of depletion or radiation injury. Here we demonstrate that on a global scale, environment appears to dictate AM development and function. Indeed, transcriptome analysis of embryonic host-derived and postnatal donor-derived AMs coexisting within the same mouse demonstrated >98% correlation and overall functional analyses were similar. However, we also identified several genes wh

SUBMITTER: Gibbings SL 

PROVIDER: S-EPMC4566811 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature