Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus.

ABSTRACT:

Background

Several studies have reported the association of PTPN2 gene with type 1 diabetes mellitus (T1DM) in many populations but not in the Chinese Han population. Therefore, the goal of our study was to replicate the reported association between 2 single-nucleotide polymorphisms (SNPs; rs478582 and rs2542151) in the PTPN2 gene and T1DM in Chinese Han children.

Material and methods

This case-control study included 141 Chinese Han children with T1DM and 282 healthy controls. Genetic variants of rs478582 and rs2542151 in PTPN2 gene were performed by PCR amplification followed by restriction fragment length polymorphism method.

Results

No difference was observed in association of rs478582 in The PTPN2 gene and T1DM. The distribution of allele frequency of rs2542151 di

SUBMITTER: Peng H 

PROVIDER: S-EPMC4566944 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature