Breast cancer incidence in a cohort of U.S. flight attendants.

ABSTRACT:

Background

Flight attendants may have elevated breast cancer incidence (BCI). We evaluated BCI's association with cosmic radiation dose and circadian rhythm disruption among 6,093 female former U.S. flight attendants.

Methods

We collected questionnaire data on BCI and risk factors for breast cancer from 2002-2005. We conducted analyses to evaluate (i) BCI in the cohort compared to the U.S. population; and (ii) exposure-response relations. We applied an indirect adjustment to estimate whether parity and age at first birth (AFB) differences between the cohort and U.S. population could explain BCI that differed from expectation.

Results

BCI was elevated but may be explained by lower parity and older AFB in the cohort than among U.S. women. BCI was not associated with exp

SUBMITTER: Schubauer-Berigan MK 

PROVIDER: S-EPMC4566958 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature