Genome-wide analysis of the heritability of amyotrophic lateral sclerosis.

ABSTRACT:

Importance

Considerable advances have been made in our understanding of the genetics underlying amyotrophic lateral sclerosis (ALS). Nevertheless, for the majority of patients who receive a diagnosis of ALS, the role played by genetics is unclear. Further elucidation of the genetic architecture of this disease will help clarify the role of genetic variation in ALS populations.

Objective

To estimate the relative importance of genetic factors in a complex disease such as ALS by accurately quantifying heritability using genome-wide data derived from genome-wide association studies.

Design, setting, and participants

We applied the genome-wide complex trait analysis algorithm to 3 genome-wide association study data sets that were generated from ALS case-control cohorts of

SUBMITTER: Keller MF 

PROVIDER: S-EPMC4566960 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature