Prognostic value and clinicopathological significance of epithelial cadherin expression in non-small cell lung cancer.

ABSTRACT:

Background

Epithelial cadherin (E-cadherin), a calcium-dependent cell-cell adhesion molecule, as an important adhesion and signaling pathway mediator plays key roles in the maintenance of tissue integrity. However, the available results of E-cadherin expression and its prognostic value on non-small cell lung cancer (NSCLC) remain controversial. Therefore, a meta-analysis of published studies investigating the prognostic value of E-cadherin expression and its association with clinicopathological characteristics with NSCLC was performed.

Methods

A literature search via PubMed, EMBASE, and MEDLINE (Ovid) databases was conducted. Data from eligible studies were extracted. Statistical analysis was performed using STATA 12.0.

Results

A total of 2412 patients from 15 studies

SUBMITTER: Qiu ZX 

PROVIDER: S-EPMC4567004 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature