Human leukocyte antigen (HLA)-G gene polymorphism in patients with non-small cell lung cancer.

ABSTRACT:

Background

Lung cancer represents the highest morbidity and mortality caused by neoplasms in the world; therefore researchers continue to search for new tools to diagnose and treat the disease. The aim of the study was to establish the role of single nucleotide polymorphisms (SNP) in the promoter region of the human leukocyte antigen (HLA)-G gene in patients with non-small cell lung cancer.

Methods

We enrolled 143 patients with a mean age of 63 years, diagnosed with non-small cell lung cancer, in the study. Adenocarcinomas made up 33% of the cases. Patients in stage III or IV of the tumor node metastasis staging system made up 59%. Two polymorphic sites in the promoter region of the HLA-G gene were genotyped (-725C>G>T and -716T>G).

Results

All genotyped SNPs were in

SUBMITTER: Kowal A 

PROVIDER: S-EPMC4567007 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature