No associations between aromatase gene polymorphisms and breast cancer risk in Saudi patients.

ABSTRACT:

Background

Cytochrome P450 (CYP)19A1 encodes aromatase, the enzyme responsible for the conversion of androgens to estrogens, and may play a role in variation in outcomes among women with breast cancer. The aim of this study was to analyze the genetic association of rs4646 (A > C) and rs700518 (Val > Val) in the CYP19A1 gene with the risk of breast cancer.

Methods

These two single nucleotide polymorphisms (SNPs) were analyzed in a primary study group of breast cancer patients and healthy control subjects. Genotypes were determined by the TaqMan SNP analysis technique. The study data were analyzed using the chi-square or t-test and logistic regression analysis by Statistical Package for the Social Sciences version 16 software.

Results

rs4646 and rs700518 had no associat

SUBMITTER: Alanazi M 

PROVIDER: S-EPMC4567226 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature