Platelet activating factors are associated with depressive symptoms in coronary artery disease patients: a hypothesis-generating study.

ABSTRACT:

Introduction

Depression is a frequent complication of coronary artery disease (CAD) with an unknown etiology. Platelet activating factor (PAF) lipids, which are associated with CAD, have recently been linked with novel proposed etiopathological mechanisms for depression such as inflammation, oxidative/nitrosative stress, and vascular endothelial dysfunction.

Methods and results

This hypothesis-generating study investigated the relationships between various PAF species and depressive symptoms in 26 CAD patients (age: 60.6±9.2 years, 69% male, mean Hamilton Depression Rating Scale [HAM-D] score: 11.8±5.2, HAM-D range: 3-20). Plasma PAF analyses were performed using high performance liquid chromatography electrospray ionization mass spectrometry in precursor ion scan. Significa

SUBMITTER: Mazereeuw G 

PROVIDER: S-EPMC4567245 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature