Molecular Characterization of Staphylococcus aureus Isolates Transmitted between Patients with Buruli Ulcer.

ABSTRACT:

Background

Buruli ulcer (BU) is a skin infection caused by Mycobacterium ulcerans. The wounds of most BU patients are colonized with different microorganisms, including Staphylococcus aureus.

Methodology

This study investigated possible patient-to-patient transmission events of S. aureus during wound care in a health care center. S. aureus isolates from different BU patients with overlapping visits to the clinic were whole-genome sequenced and analyzed by a gene-by-gene approach using SeqSphere(+) software. In addition, sequence data were screened for the presence of genes that conferred antibiotic resistance.

Principal findings

SeqSphere(+) analysis of whole-genome sequence data confirmed transmission of methicillin resistant S. aureus (MRSA) and methicillin suscepti

SUBMITTER: Amissah NA 

PROVIDER: S-EPMC4567303 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature