Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.

ABSTRACT:

Background

Obesity is associated with systemic and intestine-specific inflammation and alterations in gut microbiota, which in turn impact mucosal immunity. Nonetheless, a specific role of obesity and its interaction with genetics in the progression of Crohn's disease (CD) is unclear.

Methods

We conducted a cross-sectional study of patients with CD enrolled in Prospective Registry in Inflammatory Bowel Disease Study at Massachusetts General Hospital (PRISM). Information on diagnosis of CD and its complications were collected and confirmed through review of medical records. A genetic risk score was calculated using previously reported single-nucleotide polymorphisms-associated genome-wide with CD susceptibility. We used logistic regression to estimate the effect of body mass

SUBMITTER: Pringle PL 

PROVIDER: S-EPMC4567407 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature