Depression as sickness behavior? A test of the host defense hypothesis in a high pathogen population.

ABSTRACT: Sadness is an emotion universally recognized across cultures, suggesting it plays an important functional role in regulating human behavior. Numerous adaptive explanations of persistent sadness interfering with daily functioning (hereafter "depression") have been proposed, but most do not explain frequent bidirectional associations between depression and greater immune activation. Here we test several predictions of the host defense hypothesis, which posits that depression is part of a broader coordinated evolved response to infection or tissue injury (i.e. "sickness behavior") that promotes energy conservation and reallocation to facilitate immune activation. In a high pathogen population of lean and relatively egalitarian Bolivian forager-horticulturalists, we test whether depression and

SUBMITTER: Stieglitz J 

PROVIDER: S-EPMC4567437 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature