Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

ABSTRACT:

Purpose

To review the impact of collaborative studies on advances in the biology and treatment of acute lymphoblastic leukemia (ALL) in children and adolescents.

Methods

A review of English literature on childhood ALL focusing on collaborative studies was performed. The resulting article was reviewed and revised by the committee chairs of the major ALL study groups.

Results

With long-term survival rates for ALL approaching 90% and the advent of high-resolution genome-wide analyses, several international study groups or consortia were established to conduct collaborative research to further improve outcome. As a result, treatment strategies have been improved for several subtypes of ALL, such as infant, MLL-rearranged, Philadelphia chromosome-positive, and Philadelphia

SUBMITTER: Pui CH 

PROVIDER: S-EPMC4567699 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature