Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.

ABSTRACT: Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid leukemia (AML) have made enormous progress during the past decades. Because AML is a rare type of childhood cancer, with an incidence of approximately seven occurrences per 1 million children annually, national and international collaborative efforts have evolved. This overview describes these efforts and includes a summary of the history and contributions of each of the main collaborative pediatric AML groups worldwide. The focus is on translational and clinical research, which includes past, current, and future clinical trials. Separate sections concern acute promyelocytic leukemia, myeloid leukemia of Down syndrome, and relapsed AML. A plethora of novel antileukemic agents that have emerged, including new

SUBMITTER: Zwaan CM 

PROVIDER: S-EPMC4567700 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature