Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis.

ABSTRACT:

Background

The strategy of using fecal microbiota transplantation (FMT) for refractory ulcerative colitis (UC) remains unclear if single FMT failed to induce remission. This study aimed to evaluate the efficacy and safety of a designed step-up FMT strategy for the steroid-dependent UC.

Methods

Fifteen patients with steroid-dependent UC were enrolled, and treated with step-up FMT strategy. Follow-up clinical data was collected for a minimum of 3 months. Fecal microbiota composition before and post FMT of patients and related donors were analyzed by 16S rRNA sequencing.

Results

Eight of fourteen (57.1 %) patients achieved clinical improvement and were able to discontinue steroids following step-up FMT. One patient was lost to follow-up. Among the 8 patients who responde

SUBMITTER: Cui B 

PROVIDER: S-EPMC4567790 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature