The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4(+) T-cells.

ABSTRACT:

Background

Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4(+) T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4(+) T-cells remain unclear. Previously we have shown that HIV-1 infection of resting CD4(+) T-cells co-cultured with CD11c(+) myeloid dendritic cells (mDC) produced a population of non-proliferating T-cells with latent infection. Here we asked whether different antigen presenting cells (APC), including subpopulations of DC and monocytes, were able to induce post-integration latent infection in resting CD4(+) T-cells, and examined potential cell interactions that may be involved using RNA-seq.

Results

mDC (CD1c(+)),

SUBMITTER: Kumar NA 

PROVIDER: S-EPMC4567795 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature