Identification and validation of potential prognostic lncRNA biomarkers for predicting survival in patients with multiple myeloma.

ABSTRACT:

Background

Dysregulated long non-coding RNAs (lncRNAs) have been found to have oncogenic and/or tumor suppressive roles in the development and progression of cancer, implying their potentials as novel independent biomarkers for cancer diagnosis and prognosis. However, the prognostic significance of expression profile-based lncRNA signature for outcome prediction in patients with multiple myeloma (MM) has not yet been investigated.

Methods

LncRNA expression profiles of a large cohort of patients with MM were obtained and analyzed by repurposing the publically available microarray data. An lncRNA-focus risk score model was developed from the training dataset, and then validated in the testing and another two independent external datasets. The time-dependent receiver operating

SUBMITTER: Zhou M 

PROVIDER: S-EPMC4567800 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature