XWAS: A Software Toolset for Genetic Data Analysis and Association Studies of the X Chromosome.

ABSTRACT: XWAS is a new software suite for the analysis of the X chromosome in association studies and similar genetic studies. The X chromosome plays an important role in human disease and traits of many species, especially those with sexually dimorphic characteristics. Special attention needs to be given to its analysis due to the unique inheritance pattern, which leads to analytical complications that have resulted in the majority of genome-wide association studies (GWAS) either not considering X or mishandling it with toolsets that had been designed for non-sex chromosomes. We hence developed XWAS to fill the need for tools that are specially designed for analysis of X. Following extensive, stringent, and X-specific quality control, XWAS offers an array of statistical tests of association, inclu

SUBMITTER: Gao F 

PROVIDER: S-EPMC4567842 | biostudies-literature | 2015 Sep-Oct

REPOSITORIES: biostudies-literature