Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.

ABSTRACT:

Background

Genome-wide association studies have been used extensively to identify genetic variants linked to metabolic syndrome (MetS), but most of them have been conducted in non-Asian populations. This study aimed to evaluate the association between MetS and previously studied single nucleotide polymorphisms (SNPs), and their interaction with health-related behavior in Korean men.

Methods

Seventeen SNPs were genotyped and their association with MetS and its components was tested in 1193 men who enrolled in the study at Seoul National University Hospital.

Results

We found that rs662799 near APOA5 and rs769450 in APOE had significant association with MetS and its components. The SNP rs662799 was associated with increased risk of MetS, elevated triglyceride (TG) and lo

SUBMITTER: Son KY 

PROVIDER: S-EPMC4568070 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature