Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults.

ABSTRACT:

Background

Depressive symptoms are common in older adults and associated with poor outcomes. Although circadian genes have been implicated in depression, the relationship between circadian genes and depressive symptoms in older adults is unclear.

Methods

A cross-sectional genetic association study of 529 single nucleotide polymorphisms (SNPs) representing 30 candidate circadian genes was performed in two population-based cohorts: the Osteoporotic Fractures in Men Study (MrOS; N=270, age: 76.58±5.61 years) and the Study of Osteoporotic Fractures (SOF) in women (N=1740, 84.05±3.53 years) and a meta-analysis was performed. Depressive symptoms were assessed with the Geriatric Depression Scale categorizing participants as having none-few symptoms (0-2), some depressive symptoms (

SUBMITTER: Maglione JE 

PROVIDER: S-EPMC4568170 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature