Computational dissection of human episodic memory reveals mental process-specific genetic profiles.

ABSTRACT: Episodic memory performance is the result of distinct mental processes, such as learning, memory maintenance, and emotional modulation of memory strength. Such processes can be effectively dissociated using computational models. Here we performed gene set enrichment analyses of model parameters estimated from the episodic memory performance of 1,765 healthy young adults. We report robust and replicated associations of the amine compound SLC (solute-carrier) transporters gene set with the learning rate, of the collagen formation and transmembrane receptor protein tyrosine kinase activity gene sets with the modulation of memory strength by negative emotional arousal, and of the L1 cell adhesion molecule (L1CAM) interactions gene set with the repetition-based memory improvement. Furthermore,

SUBMITTER: Luksys G 

PROVIDER: S-EPMC4568257 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature