Ontology highlight
ABSTRACT:
SUBMITTER: Walker BA
PROVIDER: S-EPMC4568299 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nature communications 20150423
We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutational signature is seen in 3.8% of cases and is linked to the translocation-mediated deregulation of MAF and MAFB, a known poor prognostic factor. Patients with this signature have ...[more]