Role of genetic polymorphisms in hepatitis C virus chronic infection.

ABSTRACT:

Aim

To analyze the host genetics factors influencing the clinical course and the response to antiviral treatment in patients with chronic hepatitis C (CHC).

Methods

We conducted an electronic search on the PubMed and MEDLINE (2000-2014) databases and Cochrane library (2000-2014). A total of 73 articles were retrieved and their data were extensively evaluated and discussed by the authors and then analyzed in this review article.

Results

Several studies associated polymorphisms in the interleukin 28B gene on chromosome 19 (19q13.13) with a spontaneous viral clearance in acute hepatitis C and with the response to pegylated interferon (Peg-IFN)-based treatment in chronic hepatitis C patients. Other investigations demonstrated that inosine triphosphate pyrophosphatase gene

SUBMITTER: Coppola N 

PROVIDER: S-EPMC4568530 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature