Cost-effectiveness of using human papillomavirus 16/18 genotype triage in cervical cancer screening.

ABSTRACT:

Objective

Testing for human papillomavirus (HPV) 16 and 18 genotypes, which are known to cause approximately 65-70% of invasive cervical cancer cases, may allow clinicians to identify women at highest risk for underlying cervical intraepithelial neoplasia missed by Pap cytology. Our objective was to determine the cost-effectiveness of adding HPV-16 and 18 genotype triage to current cervical cancer screening strategies in the United States.

Methods

We developed a lifetime Markov model to assess the cost-effectiveness of the following cervical cancer screening algorithms: (1) liquid-based cytology (LBC), (2) LBC+HPV triage, (3) HPV+LBC triage, (4) co-screening, (5) co-screening+HPV genotyping, and (6) HPV only+HPV genotyping. Costs were estimated from a payer perspective in 20

SUBMITTER: Vijayaraghavan A 

PROVIDER: S-EPMC4568837 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature