Modelling the impact and cost-effectiveness of combination prevention amongst HIV serodiscordant couples in Nigeria.

ABSTRACT:

Objective

To estimate the impact and cost-effectiveness of treatment as prevention (TasP), pre-exposure prophylaxis (PrEP) and condom promotion for serodiscordant couples in Nigeria.

Design

Mathematical and cost modelling.

Methods

A deterministic model of HIV-1 transmission within a cohort of serodiscordant couples and to/from external partners was parameterized using data from Nigeria and other African settings. The impact and cost-effectiveness were estimated for condom promotion, PrEP and/or TasP, compared with a baseline where antiretroviral therapy (ART) was offered according to 2010 national guidelines (CD4 <350 cells/μl) to all HIV-positive partners. The impact was additionally compared with a baseline of current ART coverage (35% of those with CD4 <350 cells/μ

SUBMITTER: Mitchell KM 

PROVIDER: S-EPMC4568890 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature