Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis.

ABSTRACT:

Background

The epithelial-mesenchymal transition (EMT) has been implicated as an important process in tumor cell invasion, metastasis, and drug resistance. The transcription factor brachyury has recently been described as a driver of EMT of human carcinoma cells.

Methods

Brachyury mRNA and protein expression was analyzed in human breast carcinomas and benign tissues. The role of brachyury in breast tumor prognosis and drug resistance and the ability of brachyury-specific T cells to lyse human breast carcinoma cells were also evaluated. Kaplan-Meier analyses were used to evaluate the association between brachyury expression and survival. All statistical tests were two-sided.

Results

The level of brachyury expression in breast cancer cells was positively associated with

SUBMITTER: Palena C 

PROVIDER: S-EPMC4568990 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature