The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.
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ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC4569402 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.
Liu Ming M Lam Mandy Ka-Han MK Zhang Qinfen Q Elderfield Ruth R Barclay Wendy S WS Shaw Pang-Chui PC
PloS one 20150914 9
Influenza nucleoprotein (NP) is a major component of the ribonucleoprotein (vRNP) in influenza virus, which functions for the transcription and replication of viral genome. Compared to the nucleoprotein of influenza A (ANP), the N-terminal region of influenza B nucleoprotein (BNP) is much extended. By virus reconstitution, we found that the first 38 residues are essential for viral growth. We further illustrated the function of BNP by mini-genome reconstitution, fluorescence microscopy, electron ...[more]
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