The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis.

ABSTRACT: Protein homeostasis (proteostasis) is inextricably tied to cellular health and organismal lifespan. Aging, exposure to physiological and environmental stress, and expression of mutant and metastable proteins can cause an imbalance in the protein-folding landscape, which results in the formation of non-native protein aggregates that challenge the capacity of the proteostasis network (PN), increasing the risk for diseases associated with misfolding, aggregation, and aberrant regulation of cell stress responses. Molecular chaperones have central roles in each of the arms of the PN (protein synthesis, folding, disaggregation, and degradation), leading to the proposal that modulation of chaperone function could have therapeutic benefits for the large and growing family of diseases of protein co

SUBMITTER: Brandvold KR 

PROVIDER: S-EPMC4569545 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature