Structure-based function analysis of putative conserved proteins with isomerase activity from Haemophilus influenzae.

ABSTRACT: Haemophilus influenzae, a Gram-negative bacterium and a member of the family Pasteurellaceae, causes chronic bronchitis, bacteremia, meningitis, etc. The H. influenzae is the first organism whose genome was completely sequenced and annotated. Here, we have extensively analyzed the genome of H. influenzae using available proteins structure and function analysis tools. The objective of this analysis is to assign a precise function to hypothetical proteins (HPs) whose functions are not determined so far. Function prediction of these proteins is helpful in precise understanding of mechanisms of pathogenesis and biochemical pathways important for selecting novel therapeutic target. After an extensive analysis of H. Influenzae genome we have found 13 HPs showing high level of sequence and struct

SUBMITTER: Shahbaaz M 

PROVIDER: S-EPMC4569619 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature