Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.

ABSTRACT:

Background

Data from randomized trials are lacking on the benefits and risks of initiating antiretroviral therapy in patients with asymptomatic human immunodeficiency virus (HIV) infection who have a CD4+ count of more than 350 cells per cubic millimeter.

Methods

We randomly assigned HIV-positive adults who had a CD4+ count of more than 500 cells per cubic millimeter to start antiretroviral therapy immediately (immediate-initiation group) or to defer it until the CD4+ count decreased to 350 cells per cubic millimeter or until the development of the acquired immunodeficiency syndrome (AIDS) or another condition that dictated the use of antiretroviral therapy (deferred-initiation group). The primary composite end point was any serious AIDS-related event, serious non-AIDS-relat

SUBMITTER: INSIGHT START Study Group 

PROVIDER: S-EPMC4569751 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature