Expression Signatures of Long Noncoding RNAs in Adolescent Idiopathic Scoliosis.

ABSTRACT:

Purpose

Adolescent idiopathic scoliosis (AIS), the most common pediatric spinal deformity, is considered a complex genetic disease. Causing genes and pathogenesis of AIS are still unclear. This study was designed to identify differentially expressed long noncoding RNAs (lncRNAs) involving the pathogenesis of AIS.

Methods

We first performed comprehensive screening of lncRNA and mRNA in AIS patients and healthy children using Agilent human lncRNA + mRNA Array V3.0 microarray. LncRNAs expression in different AIS patients was further evaluated using quantitative PCR.

Results

A total of 139 lncRNAs and 546 mRNAs were differentially expressed between AIS patients and healthy control. GO and Pathway analysis showed that these mRNAs might be involved in bone mineralization, n

SUBMITTER: Liu XY 

PROVIDER: S-EPMC4569756 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature