Factors affecting time to maintenance dose in patients initiating warfarin.

ABSTRACT:

Purpose

Patients starting warfarin often experience lengthy dose-titration periods, when they are at high risk for bleeding and thromboembolism. However, relatively little is known about why some patients take longer than others to reach maintenance dose. Thus, we sought to identify social, clinical, and genetic factors associated with prolonged time to maintenance dose (TTM).

Methods

We conducted a time-to-event analysis, using a prospective cohort of patients initiating warfarin (N = 390). Additionally, we examined whether changes in post-initiation factors were associated with TTM. Finally, we performed a secondary analysis in a subcohort (N = 156) assessing the effect of adherence on TTM.

Results

No genetic or post-initiation factors were significantly associated

SUBMITTER: Finkelman BS 

PROVIDER: S-EPMC4570031 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature