The complexity, challenges and benefits of comparing two transporter classification systems in TCDB and Pfam.

ABSTRACT: Transport systems comprise roughly 10% of all proteins in a cell, playing critical roles in many processes. Improving and expanding their classification is an important goal that can affect studies ranging from comparative genomics to potential drug target searches. It is not surprising that different classification systems for transport proteins have arisen, be it within a specialized database, focused on this functional class of proteins, or as part of a broader classification system for all proteins. Two such databases are the Transporter Classification Database (TCDB) and the Protein family (Pfam) database. As part of a long-term endeavor to improve consistency between the two classification systems, we have compared transporter annotations in the two databases to understand the ration

SUBMITTER: Chiang Z 

PROVIDER: S-EPMC4570203 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature