Metabolome of human gut microbiome is predictive of host dysbiosis.

ABSTRACT:

Background

Humans live in constant and vital symbiosis with a closely linked bacterial ecosystem called the microbiome, which influences many aspects of human health. When this microbial ecosystem becomes disrupted, the health of the human host can suffer; a condition called dysbiosis. However, the community compositions of human microbiomes also vary dramatically from individual to individual, and over time, making it difficult to uncover the underlying mechanisms linking the microbiome to human health. We propose that a microbiome's interaction with its human host is not necessarily dependent upon the presence or absence of particular bacterial species, but instead is dependent on its community metabolome; an emergent property of the microbiome.

Results

Using data from a p

SUBMITTER: Larsen PE 

PROVIDER: S-EPMC4570295 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature